Most people think of Medicare drug coverage as Part D, the prescriptions you pick up at the pharmacy. But a whole category of medications never touches a pharmacy counter. These are the drugs a doctor or nurse administers to you in a clinical setting: infusions, in-office injections, and intravenous chemotherapy. Medicare covers these under Part B, the medical side, not Part D, and the way they are billed and what you pay work very differently. Understanding this split matters, because the medications involved are often expensive and the cost structure is not what most people expect.

Bryce Casson
Bryce's Take

The buy-and-bill world trips people up constantly, because they assume all their drug costs run through Part D and the $2,000 cap. They do not. An expensive infusion is a Part B drug, and on Original Medicare alone that 20 percent has no ceiling. This is one of the clearest arguments for a strong Medigap plan, or for understanding your Advantage plan's out-of-pocket maximum. If you are starting any kind of infusion or in-office injection therapy, let us make sure your coverage protects you before the bills start.

What counts as a Part B drug

Part B generally covers drugs that are administered by a healthcare provider in a clinical setting rather than something you take yourself at home. That includes drugs given by infusion in an outpatient clinic, injections you receive in the doctor's office, intravenous chemotherapy, and certain other provider-administered medications. The common thread is that a professional has to give you the drug, so it is billed as part of the medical service rather than as a prescription you fill. If you can pick it up at the pharmacy and take it yourself, it almost always falls under Part D instead.

The buy-and-bill model

Part B drugs typically run through what is called the buy-and-bill model. The provider purchases the drug, keeps it on hand, administers it to you, and then bills Medicare for both the drug and the service of giving it to you. You do not buy the drug at a pharmacy and bring it in. This is why an infusion or an in-office injection shows up on your Medicare medical claims rather than your drug plan. The provider is the one who acquired the medication and delivered it, and the billing reflects that.

What you pay: the 20 percent coinsurance

Under Original Medicare, after you meet the annual Part B deductible, you generally pay 20 percent coinsurance for Part B drugs. For an inexpensive injection that is a small amount, but for an expensive infused biologic or chemotherapy drug, 20 percent of a very large number can be a serious sum. The important thing to understand is that Original Medicare on its own has no annual out-of-pocket cap on that 20 percent, so without additional coverage your exposure on a costly Part B drug is effectively open-ended.

Why Medigap or an Advantage cap matters here

This is where your supplemental coverage does real work. If you have Original Medicare with a comprehensive Medigap plan like Plan G, the Medigap plan generally picks up the 20 percent Part B coinsurance, which can bring your cost for an expensive infused drug down close to zero after the Part B deductible. If you are in a Medicare Advantage plan instead, your Part B drug cost-sharing runs through the plan and counts toward its annual out-of-pocket maximum, which caps your total exposure for the year. Either way, the protection against that uncapped 20 percent is one of the most valuable things your coverage provides for provider-administered drugs.

Starting an infusion or in-office drug therapy?

Provider-administered drugs run under Part B with 20 percent coinsurance and no cap on Original Medicare alone. Let me make sure your Medigap or Advantage coverage actually shields you from that exposure.

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Part B drugs vs Part D drugs at a glance

FeaturePart B drugsPart D drugs
How you get itAdministered by a provider in a clinical settingSelf-administered, filled at a pharmacy
Typical examplesInfusions, in-office injections, IV chemotherapyPills, most inhalers, self-injected pens
How it is billedBuy and bill: provider buys the drug and bills MedicareYour Part D plan pays the pharmacy
Your cost-sharingGenerally 20 percent Part B coinsuranceFormulary tier copay or coinsurance
What limits your exposureMedigap or an Advantage out-of-pocket maximumThe $2,000 annual Part D out-of-pocket cap (since 2025)

Why the distinction is worth getting right

Because Part B and Part D drugs are billed and capped differently, the same condition can produce very different out-of-pocket costs depending on which pathway your treatment falls under. If you are facing a course of infused or injected medication, it pays to know it is a Part B drug and to make sure your supplemental coverage actually shields you from that 20 percent. Your exact costs depend on your specific drug, your provider, and the coverage you carry, so the most reliable way to know what you will pay is to look at your particular situation.

Frequently asked questions

Are doctor-administered drugs covered by Part B or Part D?
Drugs administered by a provider in a clinical setting, such as infusions, in-office injections, and IV chemotherapy, are generally covered under Part B. Drugs you take yourself at home, like most pills and self-injected pens, are covered under Part D. The dividing line is whether a professional has to administer it.
What is the buy-and-bill model?
Buy and bill is how Part B drugs are handled. The provider purchases the drug, administers it to you, and then bills Medicare for the drug and the service. You do not buy it at a pharmacy. That is why these medications appear on your medical claims rather than your drug plan.
How much do I pay for a Part B drug?
Under Original Medicare, you generally pay 20 percent coinsurance after meeting the Part B deductible. For an expensive infused drug that can be a large amount, and Original Medicare alone has no annual out-of-pocket cap on it. Your exact cost depends on the drug and your coverage.
Does the $2,000 Part D cap apply to Part B drugs?
No. The $2,000 annual out-of-pocket cap that began in 2025 applies to Part D drugs. Part B drugs are not subject to it. What limits your Part B drug exposure instead is a Medigap plan that covers the coinsurance, or a Medicare Advantage plan's annual out-of-pocket maximum.
Does Medigap cover Part B drugs?
A comprehensive Medigap plan like Plan G generally pays the 20 percent Part B coinsurance, which can bring your cost for an expensive provider-administered drug close to zero after the Part B deductible. This is one of the underappreciated protections a strong Medigap plan provides.
Bryce Casson
Bryce Casson
Licensed Independent Medicare Broker

Bryce Casson is an independent Medicare insurance broker who works with every major carrier. He does not represent any single insurer, which means his recommendations are based on what actually fits each client's situation, not on commissions or quotas.